Investigation of transport properties hydroxyapatite and its derivatives
E.A. Bogdanova1, T.G. Khonina2, N.A. Sabirzyanov1
1 Institute of Solid State Chemistry of the Ural Branch of RAS
2 I.Ya Postovsky Institute of Organic Synthesis Ural Branch of RAS
DOI: 10.26456/pcascnn/2023.15.659
Original article
Abstract: The article discusses the possibility of practical application of hydroxyapatite and fluorapatite as components of medicines, pharmaceutical compositions and biomaterials, the use of which is based on the transdermal delivery route of the active substance. The viscosity, density, degree of dispersion and transport properties (transmucose permeability) of hydroxyapatite and fluorapatite were estimated using modern physicochemical methods of analysis. Particular attention is paid to the joint use of the studied substances and silicon glycerolates as a conductor with pronounced transcutaneous, penetrating properties, contributing to the accumulation of locally applied drugs in biological membranes (skin, mucosa, etc.) without disturbing its structure. It is shown that the transport properties that determine the effectiveness of the action depend on the physico-chemical characteristics of the substances being penetrated. Diffusion transfer and the ability to control the processes taking place can be used for optimal design of drugs for targeted delivery through the skin and mucous membranes.
Keywords: hydroxyapatite, fluorsubstituted hydroxyapatite; siliconglycerolatas; transmucosal permeability
- Ekaterina A. Bogdanova – Ph.D., Senior Researcher, Laboratory of heterogeneous processes chemistry, Institute of Solid State Chemistry of the Ural Branch of RAS
- Tatyana G. Khonina – Dr.Sc., Leading Researcher, Laboratory of Organic Materials, I.Ya Postovsky Institute of Organic Synthesis Ural Branch of RAS
- Nail A. Sabirzyanov – Dr.Sc., Chief Researcher, Head of the Laboratory of heterogeneous processes chemistry, Institute of Solid State Chemistry of the Ural Branch of RAS
Reference:
Bogdanova, E.A. Investigation of transport properties hydroxyapatite and its derivatives / E.A. Bogdanova, T.G. Khonina, N.A. Sabirzyanov // Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials. — 2023. — I. 15. — P. 659-669. DOI: 10.26456/pcascnn/2023.15.659. (In Russian).
Full article (in Russian): download PDF file
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