Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials
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Interaction of iron-containing nanocluster polyoxometalate with doxorubicin

Yu.A. Gubarev1, N.Sh. Lebedeva1, M.O. Tonkushina2, I.D. Gagarin2, A.Yu.. Golub2, A.A. Ostroushko2

1 G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences
2 Institute of Natural Sciences and Mathematics of Ural Federal University named after the first President of Russia B.N. Yeltsin

DOI: 10.26456/pcascnn/2021.13.841

Original article

Abstract: Actual problem in the field of targeted drug delivery is transport of highly toxic drugs, with undesirable side effects, in particular antitumor medicine. The thermodynamic parameters of complexation between nanocluster polyoxometalate {Mo72Fe30}, promising as a means of targeted drug delivery, and a cytostatic agent – doxorubicin, widely used in clinical practice, were studied. The interaction of doxorubicin with {Mo72Fe30} was accompanied by an exothermic effect, which indicates an energetically favorable formation of the complex. The kinetics of the release of doxorubicin from the complex in a buffer solution with a pH corresponding to the pH value of blood was studied by fluorescence spectroscopy. The rate constants of destruction processes in the complex, accompanied by the release of doxorubicin, and further complexation of the released doxorubicin with decay products were determined. In the future, it is possible to slow down the release of doxorubicin by stabilizing the {Mo72Fe30}, for example, when it is associated with albumin.

Keywords: Nanocluster polyoxometalates, doxorubicin, complexation, targeted delivery, nanoparticles, rate constant, thermodynamic parameters

  • Yuri A. Gubarev – Ph. D., Researcher, Laboratory of Physical Chemistry of Macrocyclic Solutions, G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences
  • Natalia Sh. Lebedeva – Dr. Sc., Leading Researcher, Laboratory of Physical Chemistry of Macrocyclic Solutions, G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences
  • Margarita O. Tonkushina – Ph. D., Researcher, Department of Chemical Materials Science in Scientific Research Institute of Physics and Applied Mathematics, Institute of Natural Sciences and Mathematics of Ural Federal University named after the first President of Russia B.N. Yeltsin
  • Ilya D. Gagarin – Junior Researcher, Department of Chemical Materials Science in Scientific Research Institute of Physics and Applied Mathematic, Institute of Natural Sciences and Mathematics of Ural Federal University named after the first President of Russia B.N. Yeltsin
  • Alexey Yu.. Golub – Assistant, Department of Analytical Chemistry and Environmental Chemistry, Institute of Natural Sciences and Mathematics of Ural Federal University named after the first President of Russia B.N. Yeltsin
  • Alexander A. Ostroushko – Dr. Sc., Professor, Physical and Inorganic Chemistry Department, Institute of Natural Sciences and Mathematics of Ural Federal University named after the first President of Russia B.N. Yeltsin, Chief Researcher and Head of Department of Chemical Materials Science in Scientific Research Institute of Physics and Applied Mathematics, Institute of Natural Sciences and Mathematics of Ural Federal University named after the first President of Russia B.N. Yeltsin

Reference:

Gubarev, Yu.A. Interaction of iron-containing nanocluster polyoxometalate with doxorubicin / Yu.A. Gubarev, N.Sh. Lebedeva, M.O. Tonkushina, I.D. Gagarin, A.Yu.. Golub, A.A. Ostroushko // Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials. — 2021. — I. 13. — P. 841-851. DOI: 10.26456/pcascnn/2021.13.841. (In Russian).

Full article (in Russian): download PDF file

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