Liquid-phase synthesis of calcium phosphates in the presence of gallic acid
O.N. Musskaya, V.K. Krut’ko, I.E. Glazov, A.I. Kulak
Institute of General and Inorganic Chemistry of the National Academy of Sciences of Belarus
DOI: 10.26456/pcascnn/2023.15.1000
Original article
Abstract: Acid, medium, and basic calcium phosphates were obtained by liquid-phase synthesis from aqueous solutions of calcium chloride and ammonium hydrogen phosphate at Ca/P molar ratios of 1,0-1,67 and pH 5-11 in the presence of a polyphenol compound (gallic acid). Using X-ray phase analysis and IR spectroscopy, it has been shown that brushite is formed in a slightly acidic medium (pH 5-6) at a Ca/P molar ratio of 1,0, the unit cell size of which can decrease in the presence of gallic acid. In an alkaline environment (pH 8-11), the polyphenolic compound chelates calcium ions, which leads to the formation of amorphized calcium phosphate, which after heating at 800°C turns into β-tricalcium phosphate and hydroxyapatite. It was found that the presence of gallic acid promotes the formation of basic calcium phosphate at a lower molar ratio (Ca/P 1,5) than for stoichiometric hydroxyapatite (Ca/P 1,67). It has been shown by thermal analysis that the liquid-phase synthesis of calcium phosphates in the presence of gallic acid promotes the transformation of brushite into calcium pyrophosphate, and amorphized calcium phosphates into tricalcium phosphate and hydroxyapatite, upon high-temperature treatment.
Keywords: gallic acid, liquid-phase synthesis, brushite, amorphized calcium phosphates, hydroxyapatite, tricalcium phosphate, calcium pyrophosphate
- Olga N. Musskaya – Ph. D., Docent, Leading Researcher, Laboratory of Photochemistry and Electrochemistry, Institute of General and Inorganic Chemistry of the National Academy of Sciences of Belarus
- Valentina K. Krut’ko – Ph. D., Docent, Head of the Laboratory of Photochemistry and Electrochemistry, Institute of General and Inorganic Chemistry of the National Academy of Sciences of Belarus
- Ilya E. Glazov – Ph. D., Researcher, Laboratory of Photochemistry and Electrochemistry, Institute of General and Inorganic Chemistry of the National Academy of Sciences of Belarus
- Anatoly I. Kulak – Academician, National Academy of Sciences of Belarus, D. Sc., Professor, Director, Institute of General and Inorganic Chemistry of the National Academy of Sciences of Belarus
Reference:
Musskaya, O.N. Liquid-phase synthesis of calcium phosphates in the presence of gallic acid / O.N. Musskaya, V.K. Krut’ko, I.E. Glazov, A.I. Kulak // Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials. — 2023. — I. 15. — P. 1000-1008. DOI: 10.26456/pcascnn/2023.15.1000. (In Russian).
Full article (in Russian): download PDF file
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