Destruction of polyoxometalate {Mo₇₂Fe₃₀} as a transport agent in blood simulating media, its stabilization by albumin

M.O. Tonkushina, I.D. Gagarin, O.V. Russkikh, K.A. Belozerova, A.A. Ostroushko

Ural Federal University named after the first President of Russia B.N. Yeltsin

DOI: 10.26456/pcascnn/2020.12.885

Original article

Abstract: The creation and use of the targeted drug delivery systems based on nanocluster polyoxometalate {Mo₇₂Fe₃₀}  implies its destruction in the body, accompanied by the gradual release of the drug. The rate constants of the destruction of pure {Mo₇₂Fe₃₀} and its associate with serum albumin in solutions simulating the blood media (phosphate buffer with pH 7,4 and blood serum of cattle) were determined. The stabilization of polyoxometalate by albumin in model solutions was shown. The ratio of components in the associate {Mo₇₂Fe₃₀}–albumin was determined, it was 1,6 polyoxometalate ions per albumin molecule.

Keywords: polyoxometalate, nanocluster, {Mo72Fe30} , protein corona, targeted delivery, the rate of destruction, the rate constant of the reaction

• Margarita O. Tonkushina – Ph. D., Researcher of Department of Chemical Materials Science in Scientific Research Institute of Physics and Applied mathematics of Institute of Natural Sciences and Mathematics, Ural Federal University named after the first President of Russia B.N. Yeltsin
• Ilya D. Gagarin – Junior Researcher of Department of Chemical Materials Science in Scientific Research Institute of Physics and Applied mathematics of Institute of Natural Sciences and Mathematics, Ural Federal University named after the first President of Russia B.N. Yeltsin
• Olga V. Russkikh – Ph. D., Senior Researcher of Department of Chemical Materials Science in Scientific Research Institute of Physics and Applied mathematics of Institute of Natural Sciences and Mathematics, Ural Federal University named after the first President of Russia B.N. Yeltsin
• Ksenia A. Belozerova – student of Chemistry Department of Institute of Natural Sciences and Mathematics, Ural Federal University named after the first President of Russia B.N. Yeltsin
• Alexander A. Ostroushko – Dr. Sc., Professor, Professor of Physical and Inorganic Chemistry Department of Institute of Natural Sciences and Mathematics of Ural Federal University named after the first President of Russia B.N. Yeltsin, Chief Researcher and Head of Department of Chemical Materials Science in Scientific Research Institute of Physics and Applied Mathematics of Institute of Natural Sciences and Mathematics, Ural Federal University named after the first President of Russia B.N. Yeltsin

Reference:

Tonkushina, M.O. Destruction of polyoxometalate {Mo₇₂Fe₃₀} as a transport agent in blood simulating media, its stabilization by albumin / M.O. Tonkushina, I.D. Gagarin, O.V. Russkikh, K.A. Belozerova, A.A. Ostroushko // Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials. — 2020. — I. 12. — P. 885-892. DOI: 10.26456/pcascnn/2020.12.885. (In Russian).

Full article (in Russian): download PDF file

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