Composition, properties and features of gallstones from human body
O.A. Golovanova, S.V. Simonov
Dostoevsky Omsk State University
DOI: 10.26456/pcascnn/2025.17.831
Original article
Abstract: A study of composition, properties and characteristics of gallstones extracted from the human body has been conducted. An analysis of the chemical composition and properties of stones has been established using a set of physico-chemical methods, which may contribute to a deeper understanding of mechanisms of their formation, which are still unknown. X-ray phase analysis showed that the stones under study are mixed, with a predominance of cholesterol in their composition. Special attention is paid to the detection of calcium phosphate, which may be a key factor in understanding the pathogenesis of gallstone disease, as this compound has not previously been detected in gallstones from different collections. To confirm the group composition of the stones, infrared Fourier spectroscopy was used, which revealed the conditions of absorption of bilirubin, represented as sodium bilirubinate. In addition, the average hydrodynamic radius of the nanopowder particles from the stones in the studied collection was determined by photon correlation spectroscopy, which made it possible to evaluate their dimensional characteristics. The study also carried out selective dissolution nanopowder from stones in order to identify the most effective solvent, which is of practical importance for understanding the properties and methods of lysis. The results of the work open up new horizons for further research in the field of bioorganic nanochemistry.
Keywords: gallstones, composition, mechanisms of formation, cholesterol, degradation, hydrodynamic radius
- Olga A. Golovanova – Dr. Sc., Professor, Head of the Department of Inorganic Chemistry, Dostoevsky Omsk State University
- Sergey V. Simonov – Researcher, Department of Inorganic Chemistry, Dostoevsky Omsk State University
For citation:
Golovanova O.A., Simonov S.V. Sostav, svojstva i osobennosti zhelchnykh kamnej iz organizma cheloveka [Composition, properties and features of gallstones from human body], Fiziko-khimicheskie aspekty izucheniya klasterov, nanostruktur i nanomaterialov [Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials], 2025, issue 17, pp. 831-840. DOI: 10.26456/pcascnn/2025.17.831. ⎘
Full article (in Russian): download PDF file
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