Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials. Founded at 2009

Effect of vanadate ions on the chemical precipitation of hydroxyapatite

I.E. Glazov, A.E. Doroshenko, V.K. Krut’ko, O.N. Musskaya, A.I. Kulak

Institute of General and Inorganic Chemistry of the NAS of Belarus

DOI: 10.26456/pcascnn/2025.17.822

Original article

Abstract: Ionic forms of V+5 are promising modifying agents for hydroxyapatite, endowing the biomaterial with increased solubility and antibacterial activity. Formation of vanadate-substituted hydroxyapatites was studied under conditions of precipitation from VO3–, HPO42–-containing solution with pH 10 and maturation for 4 days. It was shown that V+5 in apatitic structure represents V2O74– and VO43– ions, for which the characteristic bands in the Raman spectra are located at 920-917 cm–1, 897-882, 873-862 and 390-367 cm–1, respectively. Incorporation of VO43–-ions in the apatitic structure occurred in the entire studied range of [V]/[P] ratios from 1/8 to 1/1 due to its isomorphism with apatitic PO43--ions. Under precipitation conditions at [V]/[P]≥1/4, the apatitic structure accommodates V2O74–-ions, which prevail in the reaction medium with pH 10. Presence of V2O74–-ions provides deviation of the apatitic Ca/(V+P) ratio from stoichiometric value of 1,67 to 1,50 and contributes to a lowering of the size of apatitic crystallites formed from 14 nm to 6 nm. Heating at 800°C of vanadate-substituted hydroxyapatites with Ca/(V+P)<1,67 is accompanied by the removal of V2O74–-ions from the apatitic structure with formation of hydroxyapatite and tricalcium phosphate vanadate.

Keywords: vanadate-substituted hydroxyapatite, vanadate ions, divanadate ions, amorphized apatite, Raman spectroscopy

  • Ilya E. Glazov – Ph. D., Senior Researcher, Laboratory of Photochemistry and Electrochemistry, Institute of General and Inorganic Chemistry of the NAS of Belarus
  • Anna E. Doroshenko – Researcher, Laboratory of Photochemistry and Electrochemistry, Institute of General and Inorganic Chemistry of the NAS of Belarus
  • Valentina K. Krut’ko – Ph. D., Assistant Professor, Head of the Laboratory of Photochemistry and Electrochemistry, Institute of General and Inorganic Chemistry of the NAS of Belarus
  • Olga N. Musskaya – Ph. D., Assistant Professor, Leading Researcher, Laboratory of Photochemistry and Electrochemistry, Institute of General and Inorganic Chemistry of the NAS of Belarus
  • Anatoly I. Kulak – Academician, D. Sc., Professor, Director, Institute of General and Inorganic Chemistry of the NAS of Belarus

For citation:

Glazov I.E., Doroshenko A.E., Krut’ko V.K., Musskaya O.N., Kulak A.I. Vliyanie vanadat-ionov na khimicheskoe osazhdenie gidroksiapatita [Effect of vanadate ions on the chemical precipitation of hydroxyapatite], Fiziko-khimicheskie aspekty izucheniya klasterov, nanostruktur i nanomaterialov [Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials], 2025, issue 17, pp. 822-830. DOI: 10.26456/pcascnn/2025.17.822. ⎘

Full article (in Russian): download PDF file

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