Study of the possibility of autoclave production of ultrafine hydroxyapatite. Assessment of the effect of technological parameters on the composition of the final product
V.M. Skachkov1, K.I. Sabanin2, I.S. Medyankina1, E.A. Bogdanova3, N.A. Sabirzyanov1
1 Institute of Solid State Chemistry of the Ural Branch of RAS
2 Ural Federal University named after the first President of Russia B. N. Yeltsin
3 JSC «Giredmet»
DOI: 10.26456/pcascnn/2025.17.752
Original article
Abstract: The article discusses a technologically simple method for the autoclave production of ultrafine hydroxyapatite, suitable for the manufacture of pharmaceutical compositions, medicines and preparations. A thermodynamic assessment of the possibility of the reaction depending on the ratio of the initial components and technological modes was carried out. The temperature range, the feed rate of the phosphoric acid solution, the optimal concentrations of the initial components, their stoichiometric ratio, which ensures a high yield of the final product and its degree of purity, have been experimentally established. The synthesis products are certified using state-of-the-art physico-chemical analysis methods. The composition of the final product was monitored by X-ray phase analysis, differential thermal analysis, the surface morphology of the synthesized products was evaluated by scanning electron microscopy, and the surface characteristics by the Brunauer-Emmett-Teller method. A patent has been obtained for a simple technological method developed as a result of the work for the production of amorphous hydroxyapatite with a high degree of purity.
Keywords: hydroxyapatite, synthesis, autoclave, technological parameters, biomaterials
- Vladimir M. Skachkov – Ph. D., Senior Researcher, Laboratory of heterogeneous processes chemistry, Institute of Solid State Chemistry of the Ural Branch of RAS
- Kirill I. Sabanin – student of the Department of Experimental Physics, Ural Federal University named after the first President of Russia B. N. Yeltsin
- Irina S. Medyankina – Ph. D., Researcher, Laboratory of promising and functional materials for CCS, Institute of Solid State Chemistry of the Ural Branch of RAS
- Ekaterina A. Bogdanova – Ph. D., Leading Researcher, Laboratory of electrochemical devices for hydrogen energy, JSC «Giredmet»
- Nail A. Sabirzyanov – doctor of engineering, Chief Researcher, Head of the Laboratory of heterogeneous processes chemistry, Institute of Solid State Chemistry of the Ural Branch of RAS
For citation:
Skachkov V.M., Sabanin K.I., Medyankina I.S., Bogdanova E.A., Sabirzyanov N.A. Izuchenie vozmozhnosti avtoklavnogo polucheniya ultradispersnogo gidroksiapatita. Otsenka vliyaniya tekhnologicheskikh parametrov na sostav konechnogo produkta [Study of the possibility of autoclave production of ultrafine hydroxyapatite. Assessment of the effect of technological parameters on the composition of the final product], Fiziko-khimicheskie aspekty izucheniya klasterov, nanostruktur i nanomaterialov [Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials], 2025, issue 17, pp. 752-763. DOI: 10.26456/pcascnn/2025.17.752. ⎘
Full article (in Russian): download PDF file
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