Spectroscopy of porous silicon nanoparticles impregnated with a drug maloben substance
M.Sh. Sattorov1, Y.M. Spivak1, Y.M. Kotcur2, A. Kuznetsov3, E.V. Flisyuk2, V.A. Moshnikov1
1 St. Petersburg Electrotechnical University «LETI»
2 St. Petersburg State Chemical and Pharmaceutical University
3 Moscow Institute of Physics and Technology (National Research University)
DOI: 10.26456/pcascnn/2024.16.995
Original article
Abstract: Using electrochemical anodic etching, porous silicon layers were formed with subsequent production of nanoparticles. The study of the nature of interaction of porous silicon nanoparticles with a new promising 4,4′-(propanediamido) sodium dibenzoate (malobene) substance was performed using infrared and Raman spectroscopy. It was revealed that during the incorporation process, an interaction occurs between the nanoparticle and maloben, during which the degree of influence of porous Si particles during joint scattering of light decreases, and the vibrational modes of the sodium 4,4′-(propanediamido) dibenzoate molecule become more intense. Characteristic absorption bands associated with the formation of chemical bonds by wave and Raman numbers were detected, and an interpretation of the obtained results from the point of view of the formation of the finished substance was proposed.
Keywords: porous silicon, nanostructured layer, nanoparticles, maloben, chemical bonds, infrared Fourier spectroscopy, Raman spectroscopy, scanning electron microscopy
- Mansurjon Sh. Sattorov – 4th year postgraduate student, Department of Micro- and Nanoelectronics, St. Petersburg Electrotechnical University «LETI»
- Yulia M. Spivak – Dr. Sc., Professor, Department of Micro- and Nanoelectronics, St. Petersburg Electrotechnical University «LETI»
- Yulia M. Kotcur – Ph. D., Senior Researcher, GMP training center, St. Petersburg State Chemical and Pharmaceutical University
- Alexey . Kuznetsov – Junior Researcher, Moscow Institute of Physics and Technology (National Research University)
- Elena V. Flisyuk – Dr. Sc., Professor, Department of Technology of Dosage Forms, St. Petersburg State Chemical and Pharmaceutical University
- Vyacheslav A. Moshnikov – Dr. Sc., Professor, Department of Micro- and Nanoelectronics, St. Petersburg Electrotechnical University «LETI»
Reference:
Sattorov, M.Sh. Spectroscopy of porous silicon nanoparticles impregnated with a drug maloben substance / M.Sh. Sattorov, Y.M. Spivak, Y.M. Kotcur, A.. Kuznetsov, E.V. Flisyuk, V.A. Moshnikov // Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials. — 2024. — I. 16. — P. 995-1003. DOI: 10.26456/pcascnn/2024.16.995. (In Russian).
Full article (in Russian): download PDF file
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