Stabilization of amorphous calcium phosphate in the structure of hydroxyapatite during liquid-phase synthesis
I.E. Glazov, V.K. Krut’ko, O.N. Musskaya, A.I. Kulak
Institute of General and Inorganic Chemistry of the NAS of Belarus
DOI: 10.26456/pcascnn/2024.16.815
Original article
Abstract: Amorphized hydroxyapatite with stabilized inclusions of amorphous calcium phosphate was obtained by a wet synthesis at pH 11. Reliable indicators of the presence of amorphous calcium phosphate in the hydroxyapatite structure includes: 1) peaks of α-tricalcium phosphate in the X-Ray Diffraction patterns after 800°C; 2) a pronounced exoeffect of crystallization of the amorphous phase at 600-850°C in the thermograms. Crystallization of amorphous calcium phosphate into α-tricalcium phosphate is inhibited by the effect of intercluster water (0,5 molecules per cluster). Under wet synthesis conditions, the key factor in stabilizing up to 16% of amorphous inclusions is a high supersaturation of the reaction medium, ensured by the mixing rate of reagent solutions of ~10-1 mol/s. The high supersaturation of the reaction medium promotes the formation of a hydroxyapatite shell around the core of amorphous calcium phosphate. The hydroxyapatite shell provides stabilization of the amorphous phase toward interaction with the mother solution for 30 days and inhibits the allotropic (α→β)-tricalcium phosphate transition at 800°C.
Keywords: amorphous calcium phosphate, wet synthesis, hydroxyapatite, core-shell, biphasic calcium phosphates
- Ilya E. Glazov – Ph. D., Senior Researcher, Laboratory of Photochemistry and Electrochemistry, Institute of General and Inorganic Chemistry of the NAS of Belarus
- Valentina K. Krut’ko – Ph. D., Assistant Professor, Head of the Laboratory of Photochemistry and Electrochemistry, Institute of General and Inorganic Chemistry of the NAS of Belarus
- Olga N. Musskaya – Ph. D., Assistant Professor, Leading Researcher, Laboratory of Photochemistry and Electrochemistry, Institute of General and Inorganic Chemistry of the NAS of Belarus
- Anatoly I. Kulak – Academician, D. Sc., Professor, Director, Institute of General and Inorganic Chemistry of the NAS of Belarus
Reference:
Glazov, I.E. Stabilization of amorphous calcium phosphate in the structure of hydroxyapatite during liquid-phase synthesis / I.E. Glazov, V.K. Krut’ko, O.N. Musskaya, A.I. Kulak // Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials. — 2024. — I. 16. — P. 815-825. DOI: 10.26456/pcascnn/2024.16.815. (In Russian).
Full article (in Russian): download PDF file
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