Influence of hyaluric acid on the structure of nanohydroxyapatite and morphological characteristics of their compositions
S.A. Gerk, O.A. Golovanova
Dostoevsky Omsk State University
DOI: 10.26456/pcascnn/2024.16.805
Original article
Abstract: Composites based on hydroxyapatite and natural biopolymers are promising materials for bone grafting. In this work, samples of hydroxyapatite were synthesized by chemical precipitation from aqueous solutions in the presence of high molecular weight hyaluronic acid (0,4-0,8 wt.%). The resulting powders are represented by carbonate-containing nanohydroxyapatite and contain 89-98 wt.% of polysaccharide. A correlation has been established between the content of hyaluronic acid in the mother solution and the crystal chemical, structural and morphological characteristics of the samples. It was revealed that, in comparison with the hydroxyapatite sample, in viscoelastic media of the polysaccharide, powders are formed that have a smaller parameter a of the hydroxyapatite crystal lattice, close in value to the stoichiometric phase. With an increase in the content of hyaluronic acid in the mother solution, the crystallinity, crystallite sizes and specific surface area of the composites decrease; their average value is 16 nm and 47 m2/g. Samples based on nanohydroxyapatite and polysaccharide consist of oval-lamellar agglomerated particles. At the maximum content of hyaluronic acid in the model solution, amorphized round conglomerates, dense in structure, are formed. The synthesized composites can be used in medical practice as osteoconductive implants, as well as to create nanoencapsulated drug delivery systems.
Keywords: nanohydroxyapatite, hyaluronic acid, composites, polymers; crystal chemical parameters, morphology
- Svetlana A. Gerk – Ph. D., Associate Professor, Senior Researcher, Inorganic Chemistry Department, Dostoevsky Omsk State University
- Olga A. Golovanova – Dr. Sc., Professor, Head of the Department of Inorganic Chemistry, Dostoevsky Omsk State University
Reference:
Gerk, S.A. Influence of hyaluric acid on the structure of nanohydroxyapatite and morphological characteristics of their compositions / S.A. Gerk, O.A. Golovanova // Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials. — 2024. — I. 16. — P. 805-814. DOI: 10.26456/pcascnn/2024.16.805. (In Russian).
Full article (in Russian): download PDF file
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