Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials
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Formation of hybrid carriers based on albumin and polyoxometalate for targeted drug delivery

M.O. Tonkushina, I.D. Gagarin, B.T.M.A.. Sharadgah, V.R. Gavrilyuk, K.A. Piunov, A.A. Ostroushko

Ural Federal University

DOI: 10.26456/pcascnn/2024.16.1025

Original article

Abstract: The use of proteins to create the targeted drug delivery systems is a promising approach in medicine and has many advantages. The formation of hybrid drug carriers based on proteins and polyoxometalates has a number of additional benefits. Polyoxometalates are able to bind both proteins and molecules of certain drugs to obtain water-soluble products without the use of toxic reagents and organic solvents. The regulation of the experimental conditions allows to control the size of the particles formed in solution. The gradual destruction of polyoxometalate {Mo72Fe30} at blood pH provides a pH-dependent mechanism for drug release from the carrier structure. In our research, we obtained bovine serum albumin associated with coordination complexes {Mo72Fe30}-doxorubicin and {Mo72Fe30}-tetracycline in aqueous solution. A decrease in the rate of the drug release in a phosphate buffer solution at pH 7.4 (blood pH) from the obtained materials compared to systems not containing albumin was observed. The data obtained in this study shed light on the formation patterns of multicomponent supramolecular systems, consisting of polyoxometalates, proteins, and drugs. The results indicate the possibility of creating hybrid carriers for targeted drug delivery based on polyoxometalates and albumin using non-covalent binding.

Keywords: {Mo72Fe30}, doxorubicin, tetracycline, albumin, targeted drug delivery, supramolecular systems

  • Margarita O. Tonkushina – Ph. D., Senior Researcher, Department of Chemical Materials Science in Scientific Research Institute of Physics and Applied Mathematics, Ural Federal University
  • Ilya D. Gagarin – Ph. D., Junior Researcher, Department of Chemical Materials Science in Scientific Research Institute of Physics and Applied Mathematics, Ural Federal University
  • Barah T.M.A.. Sharadgah – 2nd postgraduate student, Department of Medical Biochemistry and Biophysics, Ural Federal University
  • Vitaliy R. Gavrilyuk – 4th year student, Department of Fundamental and Applied Physics, Ural Federal University
  • Konstantin A. Piunov – 4th year student of the Department of Fundamental and Applied Physics, Ural Federal University
  • Alexander A. Ostroushko – Dr. Sc., Professor, Head of Department of Chemical Materials Science in Scientific Research Institute of Physics and Applied Mathematics, Ural Federal University

Reference:

Tonkushina, M.O. Formation of hybrid carriers based on albumin and polyoxometalate for targeted drug delivery / M.O. Tonkushina, I.D. Gagarin, B.T.M.A.. Sharadgah, V.R. Gavrilyuk, K.A. Piunov, A.A. Ostroushko // Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials. — 2024. — I. 16. — P. 1025-1034. DOI: 10.26456/pcascnn/2024.16.1025. (In Russian).

Full article (in Russian): download PDF file

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