Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials
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Obtainanig and study of the material based on hydroxyapatite and polycaprolactone for extrusion three- dimensional printing

N.V. Permiakov, A.I. Lebedeva, E.V. Maraeva

Saint Petersburg Electrotechnical University «LETI»

DOI: 10.26456/pcascnn/2022.14.838

Short communication

Abstract: The work is devoted to the search for a scientific and technical solution for the creation of filaments based on hydroxyapatite and polycaprolactone for extrusion three-dimensional printing. Hydroxyapatite powders were obtained by chemical precipitation using microwave radiation, and the average particle size in the powder was determined. Options for creating a filament by extrusion based on a composition of hydroxyapatite and polycaproloctone for subsequent printing of scaffolds (temporary scaffolds necessary for the formation of new functional tissues) are proposed. Images of the surface of calcium hydroxyapatite were obtained using a scanning probe microscope to assess the parameters of surface roughness, which is one of the most important factors for successful cell adhesion to the scaffold surface during osseointegration processes.

Keywords: hydroxyapatite, polycaprolactone, 3D printing, nanocomposite, scaffold, scanning probe microscopy

  • Nikita V. Permiakov – Ph. D., Docent, Micro- and Nanoelectronics Department, Saint Petersburg Electrotechnical University «LETI»
  • Anastasia I. Lebedeva – student, Micro- and Nanoelectronics Department, Saint Petersburg Electrotechnical University «LETI»
  • Evgeniya V. Maraeva – Ph. D., Docent, Micro- and Nanoelectronics Department, Saint Petersburg Electrotechnical University «LETI»

Reference:

Permiakov, N.V. Obtainanig and study of the material based on hydroxyapatite and polycaprolactone for extrusion three- dimensional printing / N.V. Permiakov, A.I. Lebedeva, E.V. Maraeva // Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials. — 2022. — I. 14. — P. 838-844. DOI: 10.26456/pcascnn/2022.14.838. (In Russian).

Full article (in Russian): download PDF file

References:

1. Tian L., Zhang Z., Tian B., Zhang X., Wang N. Study on antibacterial properties and cytocompatibility of EPL coated 3D printed PCL/HA composite scaffolds, RSC Advances, 2020, vol. 10, issue 8, pp. 4805-4816. DOI: 10.1039/C9RA10275B.
2. Zhang C., Hu Y.-Y., Cui F.-Z., Zhang S.-M., Ruan D.-K. A Study on a tissue-engineered bone using RhBMP-2 induced periosteal cells with a porous nano-hydroxyapatite/collagen/poly(l-lactic acid) scaffold, Biomedical Materials, 2006, vol. 1, no. 2, pp. 56-62. DOI: 10.1088/1748-6041/1/2/002.
3. O’Brien F.J., Harley B.A., Yannas I.V., Gibson L.J. The effect of pore size on cell adhesion in collagen-GAG scaffolds, Biomaterials, 2005, vol. 26, issue 4, pp. 433-441. DOI: 10.1016/j.biomaterials.2004.02.052.
4. Yang Y., Kulkarni A., Soraru G.D., Pearce J.M., Motta A. 3D printed SiOC(N) ceramic scaffolds for bone tissue regeneration: improved osteogenic differentiation of human bone marrow-derived mesenchymal stem cells, International Journal of Molecular Sciences, 2021, vol. 22, issue 24, art. no. 13676, 14 p. DOI: 10.3390/ijms222413676.
5. Biomaterials science: an introduction to materials in medicine, ed. by B.D. Ratner, A.S. Hoffman, F.J. Schoen, J.E. Lemons, 3 rd ed. Amsterdam, Elsevier Academic Press, 2004, 1573 p. DOI: 10.1016/C2009-0-02433-7.
6. Caetano G., Wang W., Chiang W.-H. et al. 3D-printed poly(ɛ-caprolactone)/graphene scaffolds activated with p1-latex protein for bone regeneration, 3D Printing and Additive Manufacturing. 2018, vol.5, no. 2, pp. 127-137. DOI: 10.1089/3dp.2018.0012.
7. Lenshin A.S., Maraeva E.V. Osobennosti primeneniya sorbtsionnogo analiza dlya issledovaniya razlichnykh nanomaterialov elektroniki v zavisimosti ot sostava i tekhnologicheskikh uslovij polucheniya [Application of sorption analysis in the study of various nanomaterials used in electronics depending on their composition and production conditions], Izvestiya vysshikh uchebnykh zavedenij Rossii. Radioelektronika [Journal of the Russian Universities. Radioelectronics], 2022, vol. 25, no. 1, pp. 47-53. DOI: 10.32603/1993-8985-2022-25-1-47-53.
8. Khalugarova K.N., Maraeva E.V., Zaikina A.V., Matveev V.A., Moshnikov V.A. Influence of heating time and microwave radiation power on the microstructure and phase composition of calcium-phosphorus compounds during formation, Journal of Physics: Conference Series, 2020, vol. 1697, art. no. 012050, 7 p. DOI: 10.1088/1742-6596/1697/1/012050.
9. Maraeva E., Khalugarova K. Size analysis based on sorption study data for hydroxyapatite nanoparticles, Materials Science Forum, 2021, vol. 1031, pp. 172-177. DOI: 10.4028/www.scientific.net/MSF.1031.172.
10. Permiakov N.V., Spivak Y.M., Moshnikov V.A., Shishov M.A., Sapurina I.Y. New opportunities of atomic force microscopy probes upon polyaniline functionalization, Polymer Science, Series A, 2018, vol. 60, issue 3, pp. 417-427. DOI: 10.1134/S0965545X18030082.
11. K.S. Kulyashova, Yu. P. Sharkeev. Preparation of Synthetic Hydroxyapatite to Form Biocompatible Coatings on the Implants of Medical Purpose, Chemistry for sustainable development, 2011, vol. 19, no. 4, pp. 409-415.
12. Shim J.H., Huh J.B., Park J.Y. et al. Fabrication of blendedpolycaprolactone/poly(lactic-co-glycolic acid)/beta-tricalcium phosphate thin membrane using solidfreeform fabrication technology for guided bone regeneration, Tissue Engineering Part A., 2013, vol. 19, no. 3-4, pp. 317-328. DOI: 10.1089/ten.TEA.2011.0730.

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