Composites based on calcium phosphate foam ceramic and hydroxyapatite gel
V.K. Krut’ko, L.Yu.. Maslova, O.N. Musskaya, A.I. Kulak
Institute of General and Inorganic Chemistry of the National Academy of Sciences of Belarus
DOI: 10.26456/pcascnn/2022.14.791
Original article
Abstract: Bioactive calcium phosphate composites were obtained, consisting of open-pore multiphase calcium phosphate foam ceramic based on α / β-tricalcium phosphate, β-calcium pyrophosphate, biomimetic apatite and 5% hydroxyapatite gel at a mass ratio (ceramic foam / hydroxyapatite gel) of 1:3 and 1:10. Preliminary modification of the calcium phosphate foam ceramic with biomimetic apatite in a concentrated SBF×5 solution allows increasing the static strength to 0,05 MPa with a slight decrease in porosity and maintaining the open-pore structure of polyurethane foam. Calcium phosphate composites have increased resorbability in SBF×5 and are resorbed 3–5 times faster compared to calcium phosphate foam ceramic. The presence of a significant amount of hydroxyapatite gel increases the rate of resorption of calcium phosphate foam ceramic and the ongoing processes of apatite formation with the participation of SBF×5 ions due to its high reactivity. The obtained calcium phosphate composites are used in regenerative treatments to fill bone defects in unloaded areas.
Keywords: calcium phosphate foam ceramic, tricalcium phosphate, hydroxyapatite gel, simulated body fluid, biomimetic apatite, resorbability
- Valentina K. Krut’ko – Ph. D., Assistant Professor, Head of the Laboratory of Photochemistry and Electrochemistry, Institute of General and Inorganic Chemistry of the National Academy of Sciences of Belarus
- Lyubov Yu.. Maslova – Junior Researcher, Photochemistry and Electrochemistry Laboratory, Institute of General and Inorganic Chemistry of the National Academy of Sciences of Belarus
- Olga N. Musskaya – Ph. D., Assistant Professor, Leading Researcher, Photochemistry and Electrochemistry Laboratory, Institute of General and Inorganic Chemistry of the National Academy of Sciences of Belarus
- Anatoly I. Kulak – Academician, D. Sc., Professor, Director, Institute of General and Inorganic Chemistry of the National Academy of Sciences of Belarus
Reference:
Krut’ko, V.K. Composites based on calcium phosphate foam ceramic and hydroxyapatite gel / V.K. Krut’ko, L.Yu.. Maslova, O.N. Musskaya, A.I. Kulak // Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials. — 2022. — I. 14. — P. 791-799. DOI: 10.26456/pcascnn/2022.14.791. (In Russian).
Full article (in Russian): download PDF file
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