Synthesis and physicochemical study of the cerium and cefazolin metal complex
T.V. Kryukov, M.A. Feofanova, M.I. Skobin, A.I. Ivanova
Tver State University
Abstract: In this work, a team of authors obtained and isolated in solid form a metal complex compound by the interaction of aqueous solutions of trivalent cerium chloride and sodium salt of cefazolin. Its elemental composition was determined using the X-ray spectral electron probe analysis. The thermal characteristics of this compound, the temperature of its decomposition, the composition and the method of coordination of the inner sphere of this metal complex were clarified by the methods of thermogravimetry, differential scanning calorimetry and IR spectroscopy. Based on the data obtained, the inner sphere of the metal complex contains three molecules of cefazolin and three molecules of inner-sphere water. The composition of the inner sphere corresponds to the formula [CeCzl3(H2O)3]. Taking into account IR spectroscopy data, the authors concluded that the most likely way of coordination of cefazolin to the central ion is through the amide and carboxyl groups.
Keywords: coordination compounds of rare earth elements, cefazolin, cefazolin complexes, cephalosporins
- Timofey V. Kryukov – Leading Engineer, Department of Inorganic and Analytical Chemistry, Tver State University
- Mariana A. Feofanova – Ph. D., Docent, Head of the Department of Inorganic and Analytical Chemistry, Dean of the Chemical and Technology Department, Tver State University
- Mikhail I. Skobin – Leading Engineer, Department of Inorganic and Analytical Chemistry, Tver State University
- Alexandra I. Ivanova – Ph. D, Docent, Department of Applied Physics, Tver State University
Kryukov, T.V. Synthesis and physicochemical study of the cerium and cefazolin metal complex / T.V. Kryukov, M.A. Feofanova, M.I. Skobin, A.I. Ivanova // Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials. — 2021. — I. 13. — P. 881-889. DOI: 10.26456/pcascnn/2021.13.881. (In Russian).
Full article (in Russian): download PDF file
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