Theoretical and experimental study of macromolecular nanostructures based on heparin and lanthanoids
M.I. Skobin, M.A. Feofanova, T.V. Kryukov
Tver State University
DOI: 10.26456/pcascnn/2021.13.513
Original article
Abstract: Study of synthetic and natural materials suitable for the creation of nanocarriers and their modification will provide a breakthrough in the treatment of many diseases. Glycosaminoglycans (heparin and its derivatives) are a good choice for creating nanocarriers due to their unique biological and physicochemical properties. The complexation of Pr (III), Sm (III), Eu (III) with heparin anions was studied by potentiometric titration at 37 °C and an ionic strength of 0,15 M NaCl . Significant forms and chemical equilibria were determined using the NewDALSFEK program. In the pH range from 2,7 to 5 , a complex of the type {[LnHep]}n, is formed, where Hep3- is a monomeric unit of the heparin macromolecule. Data on the stability of nanocompositions were obtained: lgβ [PrHep]=4,27±0,04, lgβ [SmHep]=4,28±0,04, lgβ [EuHep]=4,28±0,03. The M06-HF method in combination with the CSDZ+* basic set was used to perform quantum chemical modeling of the complexes.
Keywords: heparin, lanthanides, stability constant, quantum chemical calculation, anticoagulants, Hartree-Fock method
- Mikhail I. Skobin – Leading Engineer, Department of Inorganic and Analytical Chemistry, Tver State University
- Mariana A. Feofanova – Ph. D., Docent, Head of the Department of Inorganic and Analytical Chemistry, Dean of the Chemical and Technology Department, Tver State University
- Timofey V. Kryukov – Leading Engineer, Department of Inorganic and Analytical Chemistry, Tver State University
Reference:
Skobin, M.I. Theoretical and experimental study of macromolecular nanostructures based on heparin and lanthanoids / M.I. Skobin, M.A. Feofanova, T.V. Kryukov // Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials. — 2021. — I. 13. — P. 513-521. DOI: 10.26456/pcascnn/2021.13.513. (In Russian).
Full article (in Russian): download PDF file
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