Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials
Founded at 2009


Composites based on calcium phosphates and copper nanoparticles

O.N. Musskaya, V.K. Krut’ko, A.I. Kulak, E.N. Krutsko

Institute of General and Inorganic Chemistry of National Academy of Sciences of Belarus

DOI: 10.26456/pcascnn/2021.13.320

Original article

Abstract: Copper nanoparticles were synthesized by the borohydride method using polymer stabilizers (polyethylene glycol, polyvinylpyrrolidone). It was found by optical spectroscopy that copper nanoparticles obtained at a molar ratio Cu / polymer of 1:(3–6) have the highest stability (up to 1.5 months). It was shown that in the absence of polymer or at its low content (molar ratio Cu / polymer 1 : 1), the resulting nanoparticles aggregate and a precipitate forms containing copper and its oxides (Cu2O , CuO). By mechanical mixing of amorphized calcium phosphates (in powder and gel form) and copper nanoparticles (in the form of a colloidal solution), a powder composite containing Ca19Cu2H2(PO4)14 and Cu2PO4OH phases was obtained. It was shown that during the co-precipitation of calcium phosphates and copper nanoparticles, copper ions are incorporated into the crystal lattice of calcium phosphates with the formation of mixed acidic and medium salts.

Keywords: amorphized calcium phosphates, hydroxyapatite, copper nanoparticles, polyvinylpyrrolidone, polyethylene glycol, composites

  • Olga N. Musskaya – Ph. D., Assistant Professor, Leading Researcher, Laboratory of Photochemistry and Electrochemistry, Institute of General and Inorganic Chemistry of National Academy of Sciences of Belarus
  • Valentina K. Krut’ko – Ph. D., Assistant Professor, Head of the Laboratory of Photochemistry and Electrochemistry, Institute of General and Inorganic Chemistry of National Academy of Sciences of Belarus
  • Anatoly I. Kulak – Corresponding Member, D. Sc., Professor, Director, Institute of General and Inorganic Chemistry of National Academy of Sciences of Belarus
  • Evgeny N. Krutsko – Researcher, Laboratory of Photochemistry and Electrochemistry, Institute of General and Inorganic Chemistry of National Academy of Sciences of Belarus

Reference:

Musskaya, O.N. Composites based on calcium phosphates and copper nanoparticles / O.N. Musskaya, V.K. Krut’ko, A.I. Kulak, E.N. Krutsko // Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials. — 2021. — I. 13. — P. 320-328. DOI: 10.26456/pcascnn/2021.13.320. (In Russian).

Full article (in Russian): download PDF file

References:

1. Ruparelia J.P., Chatterjee A.K., Duttagupta S.P., Mukherji S. Strain specificity in antimicrobial activity of silver and copper nanoparticles, Acta Biomaterialia, 2008, vol. 4, issue 3, pp. 707-716. DOI: 10.1016/j.actbio.2007.11.006.
2. Rodhe Y., Skoglund S., Wallinder I. et al. Copper-based nanoparticles induce high toxicity in leukemic HL60 cells, Toxicology in Vitro, 2015, vol. 29, no. 7, pp. 1711-1719. DOI: 10.1016/j.tiv.2015.05.020.
3. Yegorova Ye.M., Revina A.A., Rostovshchikova T.N., Kiseleva O.I. Bakteritsidnyye i kataliticheskiye svoystva stabil'nykh metallicheskikh nanochastits v obratnykh mitsellakh [Bactericidal and catalytic properties of stable metal nanoparticles in reverse micelles], Vestnik Moskovskogo universiteta. Seriya 2. Khimiya [Moscow University Chemistry Bulletin], 2001, vol. 42, no. 5, pp. 332-338. (In Russian).
4. Mukhopadhyay R., Kazi J., Debnath M.C. Synthesis and characterization of copper nanoparticles stabilized with Quisqualis indica extract: Evaluation of its cytotoxicity and apoptosis in B16F10 melanoma cells, Biomedicine & Pharmacotherapy, 2018, vol. 97, pp. 1373-1385. DOI: 10.1016/j.biopha.2017.10.167.
5. Ameh T., Sayes C.M. The potential exposure and hazards of copper nanoparticles: A review, Environmental Toxicology and Pharmacology, 2019, vol. 71, art. no. 103220, 8 p. DOI: 10.1016/j.etap.2019.103220.
6. Veerapandian M., Sadhasivam S., Choi J., Yun K. Glucosamine functionalized copper nanoparticles: Preparation, characterization and enhancement of anti-bacterial activity by ultraviolet irradiation / M. Veerapandian, Chemical Engineering Journal, 2012, vol. 209, pp. 558-567. DOI: 10.1016/j.cej.2012.08.054.
7. Sadanand V., Rajini N., Rajulu A. Varada, Satyanarayana B. Preparation of cellulose composites with in situ generated copper nanoparticles using leaf extract and their properties, Carbohydrate Polymers, 2016, vol. 150, pp. 32-39. DOI: 10.1016/j.carbpol.2016.04.121.
8. Musskaya O.N., Kulak A.I., Krut'ko V.K. i dr. Adsorbtsionno-strukturnyye svoystva kserogeley fosfatov kal'tsiya, poluchennykh zhidkofaznym sintezom [Adsorption-structural properties of calcium phosphates xerogels obtained by liquid-phase synthesis], Fiziko-khimicheskie aspekty izucheniya klasterov, nanostruktur i nanomaterialov [Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials], 2018, issue 10, pp. 468-476. DOI: 10.26456/pcascnn/2018.10.468. (In Russian).
9. Uskokovic´ V., Uskokovic´ D.P. Nanosized hydroxyapatite and other calcium phosphates: Chemistry of formation and application as drug and gene delivery agents, Journal of Biomedical Materials Research B: Applied Biomaterials, 2011, vol. 96B, issue 1, pp. 152-191. DOI: 10.1002/jbm.b.31746.
10. Musskaya O.N., Kulak A.I., Krut’ko V.K. et al. Preparation of bioactive mesoporous calcium phosphate granules, Inorganic Materials, 2018, vol. 54, issue 2, pp. 117-124. DOI: 10.1134/S0020168518020115.
11. Dang T.M.D., Le T.T.T., Fribourg-Blanc E., Dang M.C. Synthesis and optical properties of copper nanoparticles prepared by a chemical reduction method, Advances in Natural Sciences: Nanoscience and Nanotechnology, 2011, vol. 2. – art. no. 015009, 6 p. DOI: 10.1088/2043-6262/2/1/015009.

⇐ Prevoius journal article | Content | Next journal article ⇒