Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials
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Nitrogen thermal desorption of as a control method for determination of the nanoparticle size in compositions based on zinc oxide and hydroxyapatite

E.V. Maraeva, V.A. Moshnikov

Saint Petersburg Electrotechnical University «LETI»

DOI: 10.26456/pcascnn/2021.13.294

Short communication

Abstract: In this paper we consider the possibility of using the nitrogen thermal desorption method for determining the size of nanoparticles in compositions based on hydroxyapatite and zinc oxide. The compositions in the form of tablets were obtained using a manual water press. The initial powders of hydroxyapatite were obtained by chemical deposition using a microwave radiation. Using the BET sorption method, the specific surface area of the powders is analyzed before and after pressing, and the effect of the composition formulation on the specific surface area is investigated. The calculation of the average sizes of nanoparticles in composites is given on the basis of the results of sorption measurements within the framework of the models of spherical and rod-like nanoparticles. The field of application of the materials under consideration is medicine, including the use of nanocomposites in targeted drug delivery and in bone engineering as bioactive coatings applied to the surface of a metal bioimplant.

Keywords: hydroxyapatite, zinc oxide, adsorption, specific surface area

  • Evgeniya V. Maraeva – Ph. D., Docent, Micro- and Nanoelectronics Department, Saint Petersburg Electrotechnical University «LETI»
  • Vyacheslav A. Moshnikov – , Saint Petersburg Electrotechnical University «LETI»


Maraeva, E.V. Nitrogen thermal desorption of as a control method for determination of the nanoparticle size in compositions based on zinc oxide and hydroxyapatite / E.V. Maraeva, V.A. Moshnikov // Physical and chemical aspects of the study of clusters, nanostructures and nanomaterials. – Tver: TSU, 2021. — I. 13. — P. 294-299. DOI: 10.26456/pcascnn/2021.13.294. (In Russian).

Full article (in Russian): download PDF file


1. Mallakpour S., Lormahdiabadi M. Polycaprolactone/ ZnO -folic acid nanocomposite films: fabrication, characterization, in-vitro bioactivity, and antibacterial assessment, Materials Chemistry and Physics, 2021, vol. 263, art. no. 124378, 13 p. DOI: 10.1016/j.matchemphys.2021.124378.
2. Singh A., Reshma K., Dubey A.K. Combined effect of surface polarization and ZnO addition on antibacterial and cellular response of hydroxyapatite- ZnO composites, Materials Science and Engineering: C, 2020, vol. 107, art. no. 110363, 17 p. DOI: 10.1016/j.msec.2019.110363.
3. Behnamsani A., Meshkini A. Synthesis and engineering of mesoporous ZnO@HAP heterostructure as a pH -sensitive nano-photosensitizer for chemo-photodynamic therapy of malignant tumor cells, Journal of Drug Delivery Science and Technology, 2019, vol. 53, 101200, 13p. DOI: 10.1016/j.jddst.2019.101200.
4. Cheng K., Guan Z., Weng W. et al. ZnO -nanorod composite coatings with adjustable hydrophilicity and Zn release ability, Thin Solid Films, 2013, vol. 544, pp. 260-264. DOI: 10.1016/j.tsf.2013.03.108.
5. Sarwar S., Chakraborti S., Bera S., Sheikh I. A., Hoque K. M., Chakrabarti P. The antimicrobial activity of ZnO nanoparticles against Vibrio cholerae: Variation in response depends on biotype, Nanomedicine: Nanotechnology, Biology and Medicine, 2016, vol. 12, issue 6, pp. 1499-1509. DOI: 10.1016/j.nano.2016.02.006.
6. Shitole A.A., Raut P.W., Sharma N. et al. Electrospun polycaprolactone/hydroxyapatite/ ZnO nanofibers as potential biomaterials for bone tissue regeneration, Journal of Materials Science - Materials in Medicine, 2019, vol. 30, issue 5, art. no. 51, 17 p. DOI: 10.1007/s10856-019-6255-5.
7. Saxena V., Hasan A., Pandey L.M. Effect of Zn/ ZnO integration with hydroxyapatite: a review, Materials Technology, 2018, vol. 33, issue 2, pp. 79-92. DOI: 10.1080/10667857.2017.1377972.
8. Khalugarova K.N., Maraeva E.V., Zaikina A.V., Matveev V.A., Moshnikov V.A. Influence of heating time and microwave radiation power on the microstructure and phase composition of calcium-phosphorus compounds during formation, Journal of Physics Conference Series, 2020, vol. 1697, art. no. 012050, 7 p. DOI: 10.1088/1742-6596/1697/1/012050.
9. Yukhnovets O., Semenova A.A., Levkevich E.A., Maximov A.I., Moshnikov V.A. Zinc oxide hierarchical nanostructures for photocatalysis, Journal of Physics: Conference Series, 2018, vol. 993, art. no 012009, 4 p. DOI: 10.1088/1742-6596/993/1/012009.
10. Maraeva E.V., Khalugarova K. Size analysis based on sorption study data for hydroxyapatite nanoparticles, Materials Science Forum, 2021, vol. 1031, pp. 172-177. DOI: 10.4028/
11. Maraeva E.V., Permiakov N.V., Kedruk E.Yu., Gritsenko L.V., Abdullin H.A Creating a virtual device for processing the results of sorption measurements in the study of zinc oxide nanorods, Chimica Techno Acta, 2020, vol.7, no. 4, pp. 154-158. DOI: 10.15826/chimtech.2020.7.4.03.

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